合成路线1

Treatment of deoxybenzoin (I) with hydroxylamine hydrochloride produces the corresponding oxime (II). Condensation of the dilithium derivative of (II) with methyl chloroacetate (III) generates the dihydroisoxazole (IV). Subsequent chlorosulfonation of (IV), followed by treatment with ammonia, furnishes sulfonamide (V). Then, displacement of the chloro group of (V) with silver nitrate gives rise to the target nitrate ester. Alternatively, chloride (V) is converted to alcohol (VI) by displacement with formic acid, followed by alkaline hydrolysis. Then, reaction of alcohol (VI) with in situ generated acetyl nitrate yields the corresponding nitrate.