|
【结 构 式】 
|
【药物名称】MC-5723 【化学名称】1-Hydroxy-1-[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methylphosphonic acid 【CA登记号】357966-09-7 【 分 子 式 】C8H12NO6P 【 分 子 量 】249.16174 |
【开发单位】Medicure (Originator) 【药理作用】Acute Myocardial Infarction, Treatment of, CARDIOVASCULAR DRUGS, Treatment of Disorders of the Coronary Arteries and Atherosclerosis |
合成路线1
Addition of di-tert-butyl phosphite (II) to the pyridine aldehyde (I) afforded the pyridylphosphonate (III). The tert-butyl phosphonate esters and the cyclic ketal groups of (III) were then hydrolyzed under acidic conditions to furnish the title compound.
| 【1】 Haque, W. (Medicure Inc.); Cardioprotective phosphonates and malonates. WO 0164692 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28771 | 2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5-carbaldehyde | C11H13NO3 | 详情 | 详情 | |
| (II) | 42237 | di(tert-butyl) phosphonate | 13086-84-5 | C8H19O3P | 详情 | 详情 |
| (III) | 53403 | di(tert-butyl) hydroxy(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methylphosphonate | n/a | C19H32NO6P | 详情 | 详情 |
Extended Information