Droxicainide, S-1249, AL-S-1249, -Drug Synthesis Database

【结构式】

【药物名称】Droxicainide, S-1249, AL-S-1249

【化学名称】(±)-N-(2,6-Dimethylphenyl)-1-(2-hydroxyethyl)piperidine-2-carboxamide

【CA登记号】78421-12-2

【分子式】C₁₆H₂₄N₂O₂

【分子量】276.38188

【开发单位】

【药理作用】　

合成路线1

A pyridine carboxylic acid anilide (III) can be produced by reacting a pyridine carboxylic acid chloride (I) with an aromatic amine (II). The pyridine carboxylic acid anilide (III) is hydrogenated to the corresponding piperidine carboxylic acid anilide (IV), which is thereafter hydroalkylated

参考文献中间体

【1】 Aberg, G.; Droxicainide. Drugs Fut 1983, 8, 6, 492.
【2】 af Ekenstam, B.; Aberg, A.K.G.; US 4302465 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	29205	2-pyridinecarbonyl chloride		C₆H₄ClNO	详情	详情
(II)	17527	2,6-Xylidine; 2,6-Dimethylaniline; 2,6-Dimethylphenylamine	87-62-7	C₈H₁₁N	详情	详情
(III)	61079	N-(2,6-dimethylphenyl)-2-pyridinecarboxamide		C₁₄H₁₄N₂O	详情	详情
(IV)	17533	N-(2,6-dimethylphenyl)-2-piperidinecarboxamide		C₁₄H₂₀N₂O	详情	详情

Extended Information