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【结 构 式】

【药物名称】Diacetolol hydrochloride, M&B-16942A, EU-4891

【化学名称】N-[3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide hydrochloride

【CA登记号】69796-04-9, 22568-64-5 (free base)

【 分 子 式 】C16H25ClN2O4

【 分 子 量 】344.84165

【开发单位】

【药理作用】 

合成路线1

The acetylation of 4-acetamidophenol (I) with acetyl chloride in refluxing benzene gives 4-acetoxyacetanilide (II), which by a Fries reaction with AlCl3 at 170 C is converted into 2-hydroxy-5-acetamidoacetophenone (III). (1,2) The reaction of (III) with epichlorohydrin (IV) by means of sodium ethoxide in refluxing ethanol affords 1-(2-acetyl-4-acetamidophenoxy)-2,3-epoxypropane (V), which is finally treated with isopropylamine (VI) in refluxing ethanol. (1-3)

1 Woolbridge, K.R.H.; Basil, B (May & Baker, Ltd.); ZA 6808345 .
2 Basil, B.; et al.; New series of cardioselective adrenergic beta-receptor blocking compounds. 1-(2-Acyl-4-acylaminophenoxy)3-isopropylaminopropan-2-ols. J Med Chem 1976, 19, 3, 399.
3 Woolbridge, K.R.H.; Basil, B. (May & Baker, Ltd.); BE 715205; CA 834734; CH 485663; CH 489467; FR 1570087; FR M7616; GB 1231783; GB 681537; JP 7134414; NL 6806946; ZA 6803130 .
4 Blancafort, P.; Serradell, M.N.; Castaner, J.; Weetman, D.F.; Diacetolol hydrochloride. Drugs Fut 1981, 6, 8, 467.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 21611 4'-Hydroxyacetanilide;4-Acetamidophenol;N-Acetyl-4-aminophenol;Paracetamol;Acetaminophen;p-Hydroxyacetanilide; Paracetamol; N-(4-hydroxyphenyl)acetamide 103-90-2 C8H9NO2 详情 详情
(II) 60980 4-(acetylamino)phenyl acetate C10H11NO3 详情 详情
(III) 21612 N-(3-acetyl-4-hydroxyphenyl)acetamide C10H11NO3 详情 详情
(IV) 10146 Epichlorohydrin; 2-(Chloromethyl)oxirane 106-89-8 C3H5ClO 详情 详情
(V) 60981 N-[3-acetyl-4-(2-oxiranylmethoxy)phenyl]acetamide C13H15NO4 详情 详情
(VI) 23933 2-Propanamine; Isopropylamine 75-31-0 C3H9N 详情 详情
Extended Information