Haloxazolam, CS-430, Somelin, -Drug Synthesis Database

【结构式】

【药物名称】Haloxazolam, CS-430, Somelin

【化学名称】10-Bromo-11b-(2-fluorophenyl)-2,3,5,6,7,11b-hexahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one

【CA登记号】59128-97-1

【分子式】C₁₇H₁₄BrFN₂O₂

【分子量】377.21573

【开发单位】Sankyo (Originator)

【药理作用】PSYCHOPHARMACOLOGIC DRUGS, Sedative/Hypnotics, Sleep Disorders, Treatment of

合成路线1

By reaction of 2-aminobenzophenones (I) with bromoacetyl halide (II) or tosyloxyacetyl halide (VI) to give, respectively, 2-(bromoacetylamino)benzophenones (III) or 2-(tosyloxyacetylamino)benzophenones (VII), which are treated with ethanolamine (IV) to give the compounds (V), which with acetic acid in ethanol give the desired compounds. These compounds can also be obtained from (III) and (VI) without isolation of (V)

参考文献中间体

【1】 Miyadera, T.; et al.; J Heterocycl Chem 1973, 10, 6, 85-88.
【2】 Shishoo, C.J.; et al.; Process for the manufacture of pharmacologically active new heterocyclic compounds and salts thereof. IN 151496 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	60640	(2-amino-5-bromophenyl)(2-fluorophenyl)methanone		C₁₃H₉BrFNO	详情	详情
(II)	27903	2-Bromoacetyl chloride	22118-09-8	C₂H₂BrClO	详情	详情
(III)	60641	2-bromo-N-[4-bromo-2-(2-fluorobenzoyl)phenyl]acetamide		C₁₅H₁₀Br₂FNO₂	详情	详情
(IV)	10259	Ethanol amine;Ethanolamine;2-Aminoethanol; 2-Amino-1-ethanol；2-Aminoethyl alcohol	141-43-5	C₂H₇NO	详情	详情
(V)	60642	N-[4-bromo-2-(2-fluorobenzoyl)phenyl]-2-[(2-hydroxyethyl)amino]acetamide		C₁₇H₁₆BrFN₂O₃	详情	详情
(VI)	60643	2-chloro-2-oxoethyl 4-methylbenzenesulfonate		C₉H₉ClO₄S	详情	详情
(VII)	60644	2-[4-bromo-2-(2-fluorobenzoyl)anilino]-2-oxoethyl 4-methylbenzenesulfonate		C₂₂H₁₇BrFNO₅S	详情	详情

Extended Information