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【结 构 式】 
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【药物名称】Aclatonium napadisilate, TM-723, Abovis 【化学名称】Bis[2-(2-acetoxypropionyloxy)-N,N,N-trimethylethanaminium] 1,5-naphthalenedisulfonate 【CA登记号】55077-30-0 【 分 子 式 】C30H46N2O14S2 【 分 子 量 】722.83412 |
【开发单位】Toyama (Originator) 【药理作用】Nausea and Vomiting, Treatment of, NEUROLOGIC DRUGS |
合成路线1
The reaction of dimethyl naphthalene-1,5-disulfonate (I) with dimethylaminoethanol (II) gives bis (2-hydroxyethyltrimethylammonium)naphthalene-1,5-disulfonate (III), which is then condensed with 2-acetoxypropionic anhydride (IV) in refluxing acetonitrile
| 【1】 Miura, K.; et al. (Tomaya Chem. Co., Ltd.); DE 2425983; FR 2233045; GB 1436978 FR 2233045; JP 7513320; JP 7518413; JP 7721490; JP 7785118; JP 7837334; JP 8001251; US 3903137 . |
| 【2】 Castaner, J.; Prous, J.; Aclatonium Napadisilate. Drugs Fut 1982, 7, 4, 227. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 60645 | dimethyl 1,5-naphthalenedisulfonate | C12H12O6S2 | 详情 | 详情 | |
| (II) | 44237 | 2-(dimethylamino)-1-ethanol | 108-01-0 | C4H11NO | 详情 | 详情 |
| (III) | 60646 | 2-{[2-(acetyloxy)propanoyl]oxy}-N,N,N-trimethyl-1-ethanaminium 2-hydroxy-N,N,N-trimethyl-1-ethanaminium 1,5-naphthalenedisulfonate | C25H40N2O11S2 | 详情 | 详情 | |
| (IV) | 60647 | 1-(acetyloxy)propanoic anhydride | C10H14O7 | 详情 | 详情 |
Extended Information