-Drug Synthesis Database

【结构式】

【药物名称】

【化学名称】4,5,6,7-Tetrachloro-2-cycloheptyl-1H-isoindole-1,3(2H)-dione
　　　　　　3,4,5,6-Tetrachloro-N-cycloheptylphthalimide

【CA登记号】67905-36-6

【分子式】C₁₅H₁₃Cl₄NO₂

【分子量】381.08836

【开发单位】University of Tokyo (Originator)

【药理作用】AIDS Medicines, Antidiabetic Drugs, Anti-Hepatitis Virus Drugs, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Antiobesity Drugs, Antiviral Drugs, ENDOCRINE DRUGS, METABOLIC DRUGS, Treatment of Nutritional Disorders, alpha-Glucosidase Inhibitors

合成路线1

The title phthalimide derivative was prepared by condensation of tetrachlorophthalic anhydride (I) with cycloheptylamine (II) in refluxing pyridine.

参考文献中间体

【1】 Sou, S.; et al.; alpha-Glucosidase inhibitors with a 4,5,6,7-tetrachlorophthalimide skeleton pendanted with a cycloalkyl or dicarba-closo-dodecaborane group. Chem Pharm Bull 2001, 49, 6, 791.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	51351	Tetrachlorophthalic anhydride; 4,5,6,7-Tetrachloro-1,3-isobenzofurandione	117-08-8	C₈Cl₄O₃	详情	详情
(II)	22234	cycloheptanamine; cycloheptylamine	5452-35-7	C₇H₁₅N	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)