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【结 构 式】 
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【药物名称】CRL-8275 【化学名称】2,2,2-Trifluoro-N-[2-(6-methoxy-5,10-dioxo-5,10-dihydropyrido[3,2-g]quinolin-4-yl)phenyl]acetamide 【CA登记号】 【 分 子 式 】C21H12F3N3O4 【 分 子 量 】427.34269 |
【开发单位】Lafon (Originator) 【药理作用】Oncolytic Drugs |
合成路线1
The cyclization of 4-methoxyquinoline-5,8-dione (I) with dimethylhydrazone (II) in refluxing acetic anhydride gives the target pyridoquinolinedione.
| 【1】 Bastide, J.; Darro, F.; Bontemps-Subielos, N.; Frydman, A.; Decaestecker, C.; Delfourne, E.; Kiss, R.; Synthesis and characterization of the antitumor activities of analogues of meridine, a marine pyridoacridine alkaloid. J Med Chem 2001, 44, 20, 3275. |
| 【2】 Kiss, R.; Bontemps-Subielos, N.; Frydman, A.; Darro, F.; Bastide, J.; Deflourne, E. (Laboratoires L. Lafon); Pharmaceutical compsn. based on polyaromatic cpds.. FR 2790954; WO 0055160 . |
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