|
【结 构 式】 
|
【药物名称】 【化学名称】3-(3-Aminopropionamido)-4-methoxybenzenesulfonic acid 3,4,5-trimethoxyphenyl ester 【CA登记号】312299-89-1 【 分 子 式 】C19H24N2O8S 【 分 子 量 】440.47573 |
【开发单位】Abbott (Originator) 【药理作用】Chemical Delivery Systems, DRUG DELIVERY, Drug Delivery Systems, ONCOLYTIC DRUGS, Antimitotic Drugs, Microtubule-Stabilizing Agents |
合成路线1
The condensation of 3-aminno-4-phenylsulfonyl fluoride (II) with 3,4,5-trimethoxyphenol (I) in the presence of triethylamine furnished the sulfonate ester (III). The amino group of (III) was then acylated with N-Boc-beta-alanine (IV) using EDC and HOBt to yield amide (V). Finally, acid cleavage of the N-Boc protecting group of (V) provided the title aminopropionamide.
| 【1】 Barr, K.J.; Gwaltney, S.L. II; Imade, H.M.; et al.; Novel sulfonate derivatives: Potent antimitotic agents. 221st ACS Natl Meet (April 1 2001, San Diego) 2001, Abst MEDI 135. |
| 【2】 Barr, K.J.; Steiner, B.A.; Qun, L.; Rosenberg, S.; Sham, H.; Gwaltney, S.L. II; Imade, H.M.; Woods, K.W. (Abbott Laboratories Inc.); Cell proliferation inhibitors. WO 0073264 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 37163 | 3,4,5-trimethoxyphenol | C9H12O4 | 详情 | 详情 | |
| (II) | 51178 | 4-Methoxymetanilyl fluoride; 3-Amino-4-methoxybenzenesulfonyl fluoride | 498-74-8 | C7H8FNO3S | 详情 | 详情 |
| (III) | 51179 | 3,4,5-trimethoxyphenyl 3-amino-4-methoxybenzenesulfonate | C16H19NO7S | 详情 | 详情 | |
| (IV) | 26616 | N-(tert-butoxycarbonyl)-beta-alanine | 3303-84-2 | C8H15NO4 | 详情 | 详情 |
| (V) | 51180 | 3,4,5-trimethoxyphenyl 3-([3-[(tert-butoxycarbonyl)amino]propanoyl]amino)-4-methoxybenzenesulfonate | C24H32N2O10S | 详情 | 详情 |
Extended Information