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【结 构 式】 
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【药物名称】PR-9, ME-10092 【化学名称】N1-(2-Chloro-3,4-dimethoxybenzylideneamino)guanidine acetate 【CA登记号】332395-39-8, 284042-43-9 (free base) 【 分 子 式 】C12H17ClN4O4 【 分 子 量 】316.74669 |
【开发单位】Melacure Therapeutics (Originator) 【药理作用】Acute Myocardial Infarction, Treatment of, Cardioprotective Agents, CARDIOVASCULAR DRUGS, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, Antioxidants |
合成路线1
The title compound is prepared by condensation of 2-chloro-3,4-dimethoxybenzaldehyde (I) with aminoguanidine bicarbonate (II) in the presence of HOAc in refluxing MeOH.
| 【1】 Skottner, A.; Lundstedt, T.; Seifert, E.; Veveris, M.; Piskunova, I.; Rozhkov, E.; Wikberg, J.; Pett, C.P.; Kalvins, I.; Andrianov, V.; Semenikhina, V.; Dambrova, M. (Melacure Therapeutics); Guanidine derivs. and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase. WO 0125192 . |
Extended Information