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【结 构 式】 
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【药物名称】 【化学名称】4-(4-Bromo-3-thienylmethyl)-1H-imidazole fumarate 【CA登记号】334917-95-2, 334917-94-1 (free base) 【 分 子 式 】C12H11BrN2O4S 【 分 子 量 】359.20047 |
【开发单位】Johnson & Johnson (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Non-Opioid Analgesics, alpha2A(2D)-Adrenoceptor Agonists |
合成路线1
The reaction of 4-bromothiophene-3-carboxylic acid with SOCl2 gives the corresponding acyl chloride (II), which is condensed with N,O-dimethylhydroxylamine (III) to yield the amide (IV). The Grignard condensation of (IV) with 4-imidazolylmagnesium bromide (V) affords the methanone (VI), which is reduced with NaBH4 to the corresponding carbinol (VII). Finally, this alcohol is reduced and deprotected with BH3/Me2S in dichloromethane/THF.
| 【1】 Press, J.B.; Rasmussen, C.P.; Boyd, R.E.; et al.; alpha2 Adrenoceptor agonists as potential analgesic agents. 3. Imidazolylmethylthiophenes. J Med Chem 2001, 44, 6, 863. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23827 | 4-bromo-3-thiophenecarboxylic acid | C5H3BrO2S | 详情 | 详情 | |
| (II) | 47917 | 4-bromo-3-thiophenecarbonyl chloride | C5H2BrClOS | 详情 | 详情 | |
| (III) | 13361 | (Methoxyamino)methane; N,O-Dimethylhydroxylamine | 1117-97-1 | C2H7NO | 详情 | 详情 |
| (IV) | 47918 | 4-bromo-N-methoxy-N-methyl-3-thiophenecarboxamide | C7H8BrNO2S | 详情 | 详情 | |
| (V) | 47919 | (4-bromo-3-thienyl)(1-trityl-1H-imidazol-4-yl)methanone | C27H19BrN2OS | 详情 | 详情 | |
| (VI) | 47920 | (4-bromo-3-thienyl)(1-trityl-1H-imidazol-4-yl)methanol | C27H21BrN2OS | 详情 | 详情 | |
| (VII) | 47921 | C36H44N4Ni | 详情 | 详情 |
Extended Information