DTPA-M2, -Drug Synthesis Database

【结构式】

【药物名称】DTPA-M2

【化学名称】2-[N,N-Bis[2-[N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-ylcarbamoylmethyl]-N-(carboxymethyl)amino]ethyl]amino]acetic acid

【CA登记号】

【分子式】C₁₈H₂₇N₁₁O₁₂S₄

【分子量】717.73839

【开发单位】Università degli Studi di Firenze (Originator)

【药理作用】Antiglaucoma Agents, OCULAR MEDICATIONS, Ophthalmic Drugs, Carbonic Anhydrase Type II Inhibitors, Carbonic Anhydrase Type IV Inhibitors

合成路线1

The title bis-amide was prepared by condensation of the dianhydride (I) with 5-amino-1,3,4-thiadiazole-2-sulfonamide (II).

【1】 Supuran, C.T.; Muncione, F.; Scozzafava, A.; Mincione, G.; Menabuoni, L.; Carbonic anhydrase inhibitors: Synthesis of sulfonamides incorporating DTPA tails and of their zinc complexes with powerful topical antiglaucoma properties. Bioorg Med Chem Lett 2001, 11, 4, 575.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	49150	Diethylenetriaminepentaacetic acid; N,N-Bis[2-(2,6-dioxomorpholino)ethyl]glycine	23911-26-4	C₁₄H₁₉N₃O₈	详情	详情
(II)	38281	5-amino-1,3,4-thiadiazole-2-sulfonamide		C₂H₄N₄O₂S₂	详情	详情

Extended Information