|
【结 构 式】 
|
【药物名称】 【化学名称】N-(2-Furylmethyl)-N'-(2-thiazolyl)thiourea 【CA登记号】 【 分 子 式 】C9H9N3OS2 【 分 子 量 】239.31958 |
【开发单位】Parker Hughes Institute (Originator) 【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Reverse Transcriptase Inhibitors |
合成路线1
Reaction of 2-aminothiazole (I) with thiocarbonyldiimidazole (II) in acetonitrile gave the intermediate thioimidazolide (III). This was then condensed with 2-furylmethylamine (IV) in hot DMF to yield the title thiourea derivative.
| 【1】 Venkatachalam, T.K.; Sudbeck, E.A.; Mao, C.; Uckun, F.M.; Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds. Bioorg Med Chem Lett 2001, 11, 4, 523. |
| 【2】 Uckun, F.M.; Venkatachalam, T.K. (Parker Hughes Institute); Aromatic and heterocyclic thiazolyl thiourea cpds. and use. WO 0232889 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 19795 | 2-Thiazolamine; 1,3-thiazol-2-amine; 1,3-thiazol-2-ylamine | 96-50-4 | C3H4N2S | 详情 | 详情 |
| (II) | 11990 | Di(1H-imidazol-1-yl)methanethione; 1,1'-Thiocarbonyldiimidazole | 6160-65-2 | C7H6N4S | 详情 | 详情 |
| (III) | 51395 | N-(1,3-thiazol-2-yl)-1H-imidazole-1-carbothioamide | C7H6N4S2 | 详情 | 详情 | |
| (IV) | 51396 | 1-(2-Furyl)methylamine; 2-Aminomethylfuran; 2-Furfurylamine; Furfurylamine | 617-89-0 | C5H7NO | 详情 | 详情 |
Extended Information