BTA-188, -Drug Synthesis Database

【结构式】

【药物名称】BTA-188

【化学名称】4-[2-[1-(6-Methylpyridazin-3-yl)piperidin-4-yl]ethoxy]benzaldehyde (E)-O-ethyloxime

【CA登记号】314062-80-1

【分子式】C₂₁H₂₈N₄O₂

【分子量】368.48291

【开发单位】Biota Scientific Management (Originator)

【药理作用】ANTIINFECTIVE THERAPY, Anti-Rhinovirus Drugs, Antiviral Drugs

合成路线1

Treatment of 4-hydroxybenzaldehyde (I) with O-ethylhydroxylamine produced the corresponding O-ethyloxime (II). Coupling of (II) with alcohol (III) under Mitsunobu conditions then gave the title ether.

参考文献中间体

【1】 Wu, W.-Y.; Watson, K.; Jin, B.; Krippner, G.; McConnell, D. (Biota Scientific Management Pty Ltd.); Antiviral agents. WO 0078746 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	13433	4-Hydroxybenzaldehyde; p-Hydroxybenzaldehyde	123-08-0	C₇H₆O₂	详情	详情
(II)	49088	4-hydroxybenzaldehyde O-ethyloxime		C₉H₁₁NO₂	详情	详情
(III)	49089	2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]-1-ethanol		C₁₂H₁₉N₃O	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)