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【结 构 式】 
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【药物名称】Dimethylaminoarglabin hydrochloride, Arglabin-DMA.HCl 【化学名称】(3aR,4aS,6aS,9aS,9bR)-7-(Dimethylaminomethyl)-1,4a-dimethyl-5,6,6a,7,9a,9b-hexahydro-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one hydrochloride 【CA登记号】188899-01-6, 215598-04-2 (free base) 【 分 子 式 】C17H26ClNO3 【 分 子 量 】327.85467 |
【开发单位】Institute of Phytochemistry, Kazakstan (Originator), NuOncology Labs (Originator) 【药理作用】ONCOLYTIC DRUGS, Farnesyl Transferase Inhibitors, Inhibitors of Signal Transduction Pathways |
合成路线1
Arglabin (I) was isolated from the extracts of Artemisia glabella and was purified by column chromatography followed by crystallization from hexane. Conjugate addition of dimethylamine to the methylene lactone system of (I) provided the target dimethylamino derivative, which was finally converted to the corresponding hydrochloride salt.
| 【1】 Adekenov, S.M. (Paracure, Inc.); Pharmaceutical compsns. of arglabin and arglabin derivs.. US 5902809; WO 9848789 . |
| 【2】 Shaikenov, T.E. (International Phytochemistry Research Laboratory Ltd.); Farnesyl-protein transferase inhibitors. WO 9943314 . |