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【结 构 式】 
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【药物名称】CDRI-93/478 【化学名称】1-[3-[4-(4-Fluorophenyl)piperazin-1-yl]propyl]pyrrolidin-2-one hydrochloride 【CA登记号】223525-77-7 (free base) 【 分 子 式 】C17H25ClFN3O 【 分 子 量 】341.8597 |
【开发单位】Central Drug Research Institute (Originator), Council Scientific Ind. Res. (Originator) 【药理作用】Angina pectoris, Treatment of, CARDIOVASCULAR DRUGS, Hypertension, Treatment of, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, alpha1-Adrenoceptor Antagonists |
合成路线1
The title compound was synthesized by two related methods. 2-Pyrrolidone (I) was alkylated with 1-bromo-3-chloropropane (II) using either sodium or potassium metal or potassium tert-butoxide as the base. The resultant N-(3-chloropropyl)pyrrolidone (III) was then condensed with 1-(4-fluorophenyl)piperazine (IV) in the presence of NaI and Na2CO3 to produce the desired disubstituted piperazine. Alternatively, the title compound was prepared from the known N-(3-chloropropyl)-N'-(4-fluorophenyl)piperazine (V) by condensation with 2-pyrrolidone (I) in the presence of sodium metal in hot xylene.
| 【2】 Jain, S.; Sinha, N.; Saxena, A.K.; Anand, N.; Saxena, R.M.; Dubey, M.P.; Patnaik, G.K.; Ray, M. (Council of Scientific and Industrial Research); Methods for preparing 1-[4-arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl]propanes. US 6084097 . |
| 【1】 Jain, S.; Sinha, N.; Saxena, A.K.; Anand, N.; Saxena, R.M.; Dubey, M.P.; Patnaik, G.K.; Ray, M. (Council of Scientific and Industrial Research); 1-[4-Arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl]propanes and their use in medical treatments. US 6150367 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 27397 | 2-Pyrrolidinone | 616-45-5 | C4H7NO | 详情 | 详情 |
| (II) | 10358 | 1-Bromo-3-chloropropane | 109-70-6 | C3H6BrCl | 详情 | 详情 |
| (III) | 52874 | 1-(3-chloropropyl)-2-pyrrolidinone | C7H12ClNO | 详情 | 详情 | |
| (IV) | 12143 | 1-(4-Fluorophenyl)piperazine | 2252-63-3 | C10H13FN2 | 详情 | 详情 |
| (V) | 27397 | 2-Pyrrolidinone | 616-45-5 | C4H7NO | 详情 | 详情 |
| (VI) | 45622 | 1-(3-chloropropyl)-4-(4-fluorophenyl)piperazine | C13H18ClFN2 | 详情 | 详情 |