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【结 构 式】 
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【药物名称】(R)-HI-511 【化学名称】N-(5-Bromopyridin-2-yl)-N'-[1(R)-phenylethyl]thiourea 【CA登记号】307317-61-9 【 分 子 式 】C14H14BrN3S 【 分 子 量 】336.25578 |
【开发单位】Parker Hughes Institute (Originator) 【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Reverse Transcriptase Inhibitors |
合成路线1
Condensation of 2-amino-5-bromopyridine (I) with thiocarbonyl diimidazole (II) gave rise to thioimidazolide (III), which was then condensed with (R)-1-phenylethylamine (IV) to yield the title thiourea.
| 【1】 Mao, C.; Venkatachalam, T.K.; Uckun, F.M.; Sudbeck, E.A.; Stereochemistry of halopyridyl and thiazolyl thiourea compounds is a major determinant of their potency as nonnucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem Lett 2000, 10, 18, 2071. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12123 | 5-Bromo-2-pyridinylamine; 5-Bromo-2-pyridinamine; 2-Amino-5-bromopyridine | 1072-97-5 | C5H5BrN2 | 详情 | 详情 |
| (II) | 11990 | Di(1H-imidazol-1-yl)methanethione; 1,1'-Thiocarbonyldiimidazole | 6160-65-2 | C7H6N4S | 详情 | 详情 |
| (III) | 24645 | N-(5-bromo-2-pyridinyl)-1H-imidazole-1-carbothioamide | C9H7BrN4S | 详情 | 详情 | |
| (IV) | 10039 | (1R)-1-Phenylethylamine; (1R)-1-Phenyl-1-ethanamine.; L-alpha-Phenylethylamine | 3886-69-9 | C8H11N | 详情 | 详情 |
Extended Information