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【结 构 式】 
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【药物名称】WQ-2944(free acid), WQ-3402 【化学名称】1-(5-Amino-2,4-difluorophenyl)-6-fluoro-8-methyl-7-(methylamino)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethanolamine salt 【CA登记号】208164-93-6 (free acid) 【 分 子 式 】C20H21F3N4O4 【 分 子 量 】438.40997 |
【开发单位】Wakunaga (Originator) 【药理作用】Antibacterial Drugs, ANTIINFECTIVE THERAPY, Quinolones |
合成路线1
Treatment of benzoylacetate derivative (I) with triethyl orthoformate and Ac2O yields derivative (II), which is then subjected to cyclization with N-tert-buxoxycarbonyl-2,4-difluoro-m-phenylenediamine (III) in EtOH, followed by treatment with K2CO3 in DMF, to afford dihydroquinoline ethyl carboxylate derivative (IV). Simultaneous hydrolysis and Boc removal of (IV) with HCl gives carboxylic acid (V), which is then treated with an aqueous solution of methylamine in the presence of pyridine to provide derivative (VI). Finally, the ethanolamine salt of the compound is formed by treatment of (VI) with ethanolamine and pyridine.
| 【1】 Sakae, N.; Yazaki, A.; Kuramoto, Y.; Yoshida, J.; Niino, Y.; Oshita, Y.; Hirao, Y.; Hayashi, N.; Amano, H. (Wakunaga Pharmaceutical Co., Ltd.); Novel pyridonecarboxylic acid derivs. or salts thereof and drugs containing the same as the active ingredient. EP 0945435; WO 9823592 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 45986 | ethyl 3-oxo-3-(2,4,5-trifluoro-3-methylphenyl)propanoate | C12H11F3O3 | 详情 | 详情 | |
| (II) | 45987 | ethyl (Z)-3-ethoxy-2-(2,4,5-trifluoro-3-methylbenzoyl)-2-propenoate | C15H15F3O4 | 详情 | 详情 | |
| (III) | 38179 | tert-butyl 5-amino-2,4-difluorophenylcarbamate | C11H14F2N2O2 | 详情 | 详情 | |
| (IV) | 45988 | ethyl 1-[5-[(tert-butoxycarbonyl)amino]-2,4-difluorophenyl]-6,7-difluoro-8-methyl-4-oxo-1,4-dihydro-3-quinolinecarboxylate | C24H22F4N2O5 | 详情 | 详情 | |
| (V) | 45989 | 1-(5-amino-2,4-difluorophenyl)-6,7-difluoro-8-methyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C17H10F4N2O3 | 详情 | 详情 | |
| (VI) | 45990 | 1-(5-amino-2,4-difluorophenyl)-6-fluoro-8-methyl-7-(methylamino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C18H14F3N3O3 | 详情 | 详情 | |
| (VII) | 10259 | Ethanol amine;Ethanolamine;2-Aminoethanol; 2-Amino-1-ethanol；2-Aminoethyl alcohol | 141-43-5 | C2H7NO | 详情 | 详情 |