AWD-34-022, -Drug Synthesis Database

【结构式】

【药物名称】AWD-34-022

【化学名称】6-(2-Chlorobenzyl)-3,6-dihydro-4H-pyrazolo[3,4-d][1,2,3]triazin-4-one

【CA登记号】

【分子式】C₁₁H₈ClN₅O

【分子量】261.67231

【开发单位】Asta Medica (Originator)

【药理作用】Antiepileptic Drugs, NEUROLOGIC DRUGS, Drugs Acting on Adenosine Receptors, Sodium Channel Blockers

合成路线1

Benzyl pyrazole derivative (III) was prepared by alkylation of 3-aminopyrazole-4-carboxamide (I) with 2-chlorobenzyl chloride (II) under phase-transfer conditions. Diazotization of (III) with NaNO2/HCl then gave the title pyrazolotriazinone.

参考文献中间体

【1】 Lankau, H.-J.; Arnold, T.; Rostock, A.; Unverferth, K.; Kronbach, T.; Bartsch, R. (Arzneimittelwerk Dresden GmbH); Pyrazolo[3,4-d][1,2,3]triazines with anticonvulsive action and methods for producing the same. DE 19924872; WO 0073309 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	46034	3-amino-1H-pyrazole-4-carboxamide		C₄H₆N₄O	详情	详情
(II)	10205	1-Chloro-2-(chloromethyl)benzene; 2-Chlorobenzyl chloride	611-19-8	C₇H₆Cl₂	详情	详情
(III)	46035	3-amino-1-(2-chlorobenzyl)-1H-pyrazole-4-carboxamide		C₁₁H₁₁ClN₄O	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)