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【结 构 式】 
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【药物名称】Gallium maltolate, GaM 【化学名称】Tris[3-(hydroxy-kappaO)-2-methyl-4H-pyran-4-onato-kappaO4]gallium 【CA登记号】108560-70-9 【 分 子 式 】C18H15GaO9 【 分 子 量 】445.03485 |
【开发单位】Titan (Proprietary), GeoMed (Originator) 【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Bladder Cancer Therapy , Bone Diseases, Treatment of, Lymphoma Therapy, METABOLIC DRUGS, Multiple Myeloma Therapy, Oncolytic Drugs, Prostate Cancer Therapy, Treatment of Paget's Disease, DNA Alkylating Drugs, Metal Complexes, Ribonucleoside-Diphosphate Reductase Inhibitors |
合成路线1
The title gallium complex was prepared by mixing solutions of maltol (I) and a soluble gallium salt, such as gallium chloride or gallium nitrate, followed by neutralization with Na2CO3.
| 【1】 Finnegan, M.M.; et al.; Neutral water-soluble post-transition-metal chelate complexes of medical interest: Aluminum and gallium tris(3-hydroxy-4-pyronates). Inorg Chem 1987, 26, 20, 2171. |
| 【2】 Bernstein, L.R.; Powder X-ray crystallography of gallium 3-hydroxy-4-pyronates. Powder Diffr 1995, 10, 2, 140. |
| 【3】 Tanner, T.; Godfrey, C.; Noll, B.; Bernstein, L.R.; Chemistry and pharmacokinetics of gallium maltolate, a compound with high oral gallium biovailability. Met-Based Drugs 2000, 7, 1, 33. |
| 【4】 Bernstein, L.R. (GeoMed, Inc.); Methods and compsns. to inhibit keratinocyte proliferation. WO 9804263; WO 9804264 . |