|
【结 构 式】 
|
【药物名称】K-7174 【化学名称】1,4-Bis[5-(3,4,5-trimethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine 【CA登记号】191089-59-5, 191089-60-8 (diHCl) 【 分 子 式 】C33H48N2O6 【 分 子 量 】568.76031 |
【开发单位】Kowa (Originator) 【药理作用】Atherosclerosis Therapy, CARDIOVASCULAR DRUGS, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, Cell Adhesion Inhibitors, VCAM-1 Antagonists |
合成路线1
The title compound was synthesized by alkylation of homopiperazine (I) with (E)-5-(3,4,5-trimethoxyphenyl)-4-pentenyl bromide (II) in the presence of KI and K2CO3 in hot DMF.
| 【1】 Nakao, H.; Umetani, M.; Suda, M.; Nagoya, T. (Kowa Co., Ltd.); Cell adhesion inhibitor. EP 0774257; JP 1997143075; US 5723465 . |
Extended Information