【结 构 式】 |
【药物名称】Ro-09-3024 【化学名称】5-[N-(6,6-Dimethyl-2,4-heptadiynyl)-N-methylamino]-1,2,3,4-tetrahydroquinolin-2-one 【CA登记号】 【 分 子 式 】C19H22N2O 【 分 子 量 】294.39999 |
【开发单位】Chugai (Originator) 【药理作用】Antifungal Agents, ANTIINFECTIVE THERAPY |
合成路线1
The Wittig reaction of 2,6-dinitrobenzaldehyde (I) with (ethoxycarbonylmethylene)triphenylphosphorane (A) produced methyl 2,6-dinitrocinnamate (II). Hydrogenation of the nitro groups and the olefinic double bond of (II) with concomitant cyclization furnished the tetrahydroquinolinone (III). Reductive alkylation of (III) with 6,6-dimethylheptadiynal (IV) and sodium cyanoborohydride produced the secondary amine (V). Finally, the N-methyl group was introduced by a second reductive alkylation with formaldehyde.
【1】 Masabuchi, K.; Umeda, I.; Taniguchi, M.; et al.; Synthesis and structure-activity relationships of novel fungal chitin synthase inhibitors. Bioorg Med Chem Lett 2000, 10, 13, 1459. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(A) | 14689 | Methyl (triphenylphosphoranylidene)acetate; (methoxycarbonylmethylene)triphenylphosphorane;Methyl 2-(triphenyl-lambda(5)-phosphanylidene)acetate | 2605-67-6 | C21H19O2P | 详情 | 详情 |
(I) | 39891 | 2,6-dinitrobenzaldehyde | 606-31-5 | C7H4N2O5 | 详情 | 详情 |
(II) | 44995 | methyl (E)-3-(2,6-dinitrophenyl)-2-propenoate | C10H8N2O6 | 详情 | 详情 | |
(III) | 44996 | 5-amino-3,4-dihydro-2(1H)-quinolinone | C9H10N2O | 详情 | 详情 | |
(IV) | 44997 | 6,6-dimethyl-2,4-heptadiynal | C9H10O | 详情 | 详情 | |
(V) | 44998 | 5-[(6,6-dimethyl-2,4-heptadiynyl)amino]-3,4-dihydro-2(1H)-quinolinone | C18H20N2O | 详情 | 详情 |
Extended Information