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The synthesis of SLV308 was obtained as follows: The first step is the reduction of just one nitro group, which was accomplished by treating 2,6-dinitrophenol (I) with sodium sulfide in the presence of sodium hydrogencarbonate dissolved in a water/MeOH mixture to yield 2-amino-6-nitro-phenol (II) in 62%. To construct the heterocyclic ring, (II) was reacted with carbonyldiimidazole in dry tetrahydrofuran to give the nitro benzoxazolinone (III) almost quantitatively. The reduction of the nitro group of (III) was performed in acetone/Raney-Ni, resulting in the corresponding aniline (IV) (72%). Transforming the aniline (IV) into the piperazine was done by heating (IV) and bis(2-chloroethyl)amine in chlorobenzene at reflux temperature; after 70 hours the desired piperazine (V) was obtained after chromatographic purification in 60% yield. The last step, introduction of the methyl group, was achieved by a reductive amination; formaldehyde, sodium triacetoxyborohydride and triethylamine dissolved in dichloroethane were added to (V). After work-up, chromatographic purification and subsequent treatment with ethanolic HCl, SLV308 was isolated in 81% yield.