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【结 构 式】 
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【药物名称】 【化学名称】1-(6-Amino-1,3-benzodioxol-5-yl)-3-(3-methoxyphenyl)-2(E)-propen-1-one 【CA登记号】204841-35-0 【 分 子 式 】C17H15NO4 【 分 子 量 】297.3134 |
【开发单位】University of North Carolina (Originator) 【药理作用】ONCOLYTIC DRUGS |
合成路线1
The desired 2'-amino chalcone is synthesized by a base-catalyzed condensation of 2-amino acetophenone (I) and benzaldehyde (II) by means of aqueous NaOH in EtOH.
| 【1】 Xia, Y.; et al.; Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3, 4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents. J Med Chem 1998, 41, 7, 1155. |
| 【2】 Xia, P.; Xia, Y.; Lee, K.-H.; Bastow, K.F.; Nakanishi, Y.; Yang, Z.-Y.; Antitumor agents. Part 202: Novel 2'-amino chalcones: Design, synthesis and biological evaluation. Bioorg Med Chem Lett 2000, 10, 8, 699. |
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