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【结 构 式】 
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【药物名称】S-33113-1, S-33113 【化学名称】6'-Ethoxyspiro[cyclohexane-1,2'(1'H)-quinoline] 【CA登记号】264253-97-6, 264253-71-6 (HCl) 【 分 子 式 】C16H21NO 【 分 子 量 】243.35187 |
【开发单位】Servier (Originator) 【药理作用】Cerebrovascular Diseases, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, Lipid Peroxidation Inhibitors |
合成路线1
Condensation of phenetidine (I) with 1-ethynyl-1-chlorocyclohexane (II) by means of CuCl and Et3N gave the propargyl aniline (III). This was then cyclized in the presence of copper catalyst in refluxing toluene to furnish the target dihydroquinoline.
| 【1】 Dorey, G.; Lestage, P.; Casara, P.; Lockhart, B.; New quinolinic derivatives as centrally active antioxidants. Bioorg Med Chem Lett 2000, 10, 9, 935. |
| 【2】 Lestage, P.; Dorey, G.; Casara, P.; Lockhart, B. (ADIR et Cie.); Derivs. of dihydro- and tetrahydrochinoline as a medicinal antioxidants. EP 0995743; FR 2784988; JP 2000128865 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 45939 | 4-Aminophenetole; 1-Amino-4-ethoxybenzene; 4-Aminoethoxybenzene; 4-Ethoxyphenylamine; p-Phenetidine; 4-Ethoxyaniline | 156-43-4 | C8H11NO | 详情 | 详情 |
| (II) | 51033 | 2-[3-[1,1'-biphenyl]-4-yl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]acetyl chloride | C24H16ClF3N2O | 详情 | 详情 | |
| (III) | 51034 | C48H80O40 | 详情 | 详情 |
Extended Information