|
【结 构 式】 
|
【药物名称】NO-prednisolone, NCX-1015 【化学名称】11beta,17alpha-Dihydroxy-21-[4-(nitrooxymethyl)benzoyloxy]pregna-1,4-diene-3,20-dione 【CA登记号】 【 分 子 式 】C29H33NO9 【 分 子 量 】539.58766 |
【开发单位】NicOx (Originator), William Harvey Research Institute (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Antiarthritic Drugs, Asthma Therapy, GASTROINTESTINAL DRUGS, Inflammatory Bowel Disease, Agents for, RESPIRATORY DRUGS, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Glucocorticoids, Nitric Oxide Donors |
合成路线1
The esterification of prednisolone (I) with 4-(chloromethyl)benzoyl chloride (II) by means of TEA in THF gives the corresponding benzoate (II),which is treated with silver nitrate in refluxing acetonitrile/THF to yield the target nitrate ester.
| 【1】 Del Soldato, P.; Ongini, E. (NicOx SA); New corticosteroids. WO 0364443 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13538 | (8S,9S,10R,11S,13S,14S,17R)-17-Glycoloyl-11,17-dihydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; Prednisolone | 50-24-8 | C21H28O5 | 详情 | 详情 |
| (II) | 49112 | 4-(Chloromethyl)benzoyl chloride; p-(Chloromethyl)benzoyl chloride | 876-08-4 | C8H6Cl2O | 详情 | 详情 |
| (III) | 64757 | 2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl 4-(chloromethyl)benzoate | C29H33ClO6 | 详情 | 详情 |
Extended Information