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【结 构 式】 
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【药物名称】NSC-D703786, NSC-703786, 5F-DF-203, 5F-203 【化学名称】4-(5-Fluorobenzothiazol-2-yl)-2-methylphenylamine 【CA登记号】260443-89-8 【 分 子 式 】C14H11FN2S 【 分 子 量 】258.31957 |
【开发单位】National Cancer Institute (Originator), University of Nottingham (Originator) 【药理作用】ONCOLYTIC DRUGS |
合成路线1
Jacobsen radical cyclization of thiobenzanilide (I) in the presence of potassium ferricyanide produced a mixture of the desired benzothiazole (III) and minor amounts of its regioisomer (II). An alternative regiospecific synthesis of (III) consisted in the intramolecular cyclization of the ortho-bromo thiobenzanilide (IV) by means of NaH in hot NMP. Further reduction of the nitro group of (III) using SnCl2 in EtOH gave the desired amino compound.
| 【1】 Hutchinson, I.; et al.; The regiospecific synthesis of 5- and 7-monosubstituted and 5,6-disubstituted 2-arylbenzothiazoles. Tetrahedron Lett 2000, 41, 3, 425. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 46951 | N-(3-fluorophenyl)-3-methyl-4-nitrobenzenecarbothioamide | C14H11FN2O2S | 详情 | 详情 | |
| (II) | 46952 | 7-fluoro-2-(3-methyl-4-nitrophenyl)-1,3-benzothiazole | C14H9FN2O2S | 详情 | 详情 | |
| (III) | 46953 | 5-fluoro-2-(3-methyl-4-nitrophenyl)-1,3-benzothiazole | C14H9FN2O2S | 详情 | 详情 | |
| (IV) | 46954 | N-(2-bromo-5-fluorophenyl)-3-methyl-4-nitrobenzenecarbothioamide | C14H10BrFN2O2S | 详情 | 详情 |
合成路线2
The reaction of 5-fluorobenzothiazol-2-amine (I) with KOH in refluxing water gives the disulfide (II), which is treated with 3-methyl-4-nitrobenzoyl chloride (III) in refluxing pyridine to yield the bis-benzamide (IV). Finally, this compound is reductively cyclized by reaction with SnCl2 and HCl in ethanol/water to afford the target aminophenyl benzothiazole.
| 【1】 Chua, M.-S.; Westwell, A.D.; Hutchinson, I.P.; Stevens, M.F.G.; Poole, T.D. (Cancer Research Campaign Technology Ltd.); Substd. 2-arylbenzazole cpds. and their use as antitumour agents. WO 0114354 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 47594 | 5-fluoro-1,3-benzothiazol-2-amine; 5-fluoro-1,3-benzothiazol-2-ylamine | C7H5FN2S | 详情 | 详情 | |
| (II) | 47595 | 2-[(2-amino-4-fluorophenyl)disulfanyl]-5-fluoroaniline; 2-[(2-amino-4-fluorophenyl)disulfanyl]-5-fluorophenylamine | C12H10F2N2S2 | 详情 | 详情 | |
| (III) | 51998 | 3-Methyl-4-nitrobenzamide | 99584-85-7 | C8H8N2O3 | 详情 | 详情 |
| (IV) | 47597 | N-[5-fluoro-2-([4-fluoro-2-[(3-methyl-4-nitrobenzoyl)amino]phenyl]disulfanyl)phenyl]-3-methyl-4-nitrobenzamide | C28H20F2N4O6S2 | 详情 | 详情 |