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【结 构 式】 
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【药物名称】D-58 【化学名称】1-(2,4,6-Trihydroxyphenyl)-2-(4-methoxyphenyl)ethan-1-one 【CA登记号】15485-66-2 【 分 子 式 】C15H14O5 【 分 子 量 】274.27583 |
【开发单位】Parker Hughes Institute (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Asthma Therapy, Drugs for Allergic Rhinitis, RESPIRATORY DRUGS, Treatment of Upper Respiratory Tract Disorders, Mediator Release Inhibitors, Syk Kinase Inhibitors |
合成路线1
The target product can be obtained either by condensation of phloroglucinol (I) with carboxylic acid (II) by means of zinc chloride (ZnCl2) and phosphoryl chloride (POCl3) (1) or by reaction of phloroglucinol (I) with acetonitrile derivative (III), boron trifluoride-etherate (BF3-Et2O) and hydrogen chloride in ether.
| 【1】 Mohanty, S.; Grover, S.K.; An improved procedure for the acylation on phenols using boron trifluoride-etherate. Curr Sci 1988, 57, 10, 537. |
| 【2】 Devi, N.; et al.; Synthesis of deoxybenzoins. Indian J Chem 1993, 32B, 8, 874. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11799 | 1,3,5-Benzenetriol; Fluoroglucinol | 108-73-6 | C6H6O3 | 详情 | 详情 |
| (II) | 34793 | 2-(4-methoxyphenyl)acetic acid; p-Methoxyphenyl formate; Homoanisic acid; p-Methyl benzyl formate; 4-methoxyphenylacetic acid; 4-methoxybenzeneacetic acid; p-methoxyphenylacetic acid | 104-01-8 | C9H10O3 | 详情 | 详情 |
| (III) | 23242 | 2-(4-methoxyphenyl)acetonitrile; 4-methoxybenzeneacetonitrile | 104-47-2 | C9H9NO | 详情 | 详情 |
Extended Information