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【结 构 式】 
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【药物名称】 【化学名称】1-(3,4-Dichlorobenzyl)-3,4-dihydro-1H-2,1,3-benzothiadiazin-4-one S,S-dioxide 【CA登记号】 【 分 子 式 】C14H10Cl2N2O3S 【 分 子 量 】357.2174 |
【开发单位】Almirall Prodesfarma (Originator), CSIC (Originator) 【药理作用】PHARMACOLOGICAL TOOLS, Phosphodiesterase Inhibitors |
合成路线1
Benzothiadiazine S,S-dioxide (II) was obtained by a two-step condensation of methyl anthranylate (I) and sulfamoyl chloride following a reported procedure (1). The alkylation of (II) with 3,4-dichlorobenzyl chloride (III) in the presence of NaHCO3 furnished the title compound.
| 【1】 J Am Chem Soc 1962, 84, 1994-2000. |
| 【2】 Castro, A.; Gil, C.; Martinez, A.; et al.; Benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides: First phosphodiesterase 7 inhibitors. J Med Chem 2000, 43, 4, 683. |
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