|
【结 构 式】 
|
【药物名称】SC-22716 【化学名称】1-[2-(Biphenyl-4-yloxy)ethyl]pyrrolidine 【CA登记号】 【 分 子 式 】C18H21NO 【 分 子 量 】267.37417 |
【开发单位】Pfizer (Originator) 【药理作用】Antiarthritic Drugs, Antipsoriatics, DERMATOLOGIC DRUGS, GASTROINTESTINAL DRUGS, Inflammatory Bowel Disease, Agents for, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Leukotriene A4 Hydrolase Inhibitors |
合成路线1
The title compound was prepared by alkylation of 4-phenylphenol (I) with 1-(2-chloroethyl)pyrrolidine.HCl (II) in the presence of NaH in hot DMF.
| 【1】 Penning, T.D.; Chandrakumar, N.S.; Chen, B.B.; et al.; Structure-activity relationship studies on 1-[2-(4-phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A4 (LTA4) hydrolase. J Med Chem 2000, 43, 3, 721. |
Extended Information