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【结 构 式】 
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【药物名称】 【化学名称】1-[2-(Diphenylmethoxy)ethyl]-2-methyl-5-nitro-1H-imidazole nitrate 【CA登记号】 【 分 子 式 】C19H20N4O6 【 分 子 量 】400.39445 |
【开发单位】Università degli Studi "La Sapienza" (Originator), Università degli Studi di Cagliari (Originator), Università degli Studi di Siena (Originator) 【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Reverse Transcriptase Inhibitors |
合成路线1
Reaction of carbinol derivative (I) with 1-(2-hydroxyethyl)-2-methyl-5-nitro-1H-imidazole (II) and TsOH in benzene allows preparation of the target compound.
| 【1】 La Colla, P.; Artico, M.; Marceddu, T.; Silvestri, R.; Massa, S.; De Montis, F.; 1-[2-(Diphenylmethoxy)ethyl]-2-methyl-5-nitroimidazole: A potent lead for the design of novel NNRTIs. Bioorg Med Chem Lett 2000, 10, 3, 253. |
Extended Information