【结 构 式】 |
【药物名称】 【化学名称】2-(2-Oxo-2H-1-benzopyran-3-ylcarboxamido)benzoic acid methyl ester 【CA登记号】 【 分 子 式 】C18H13NO5 【 分 子 量 】323.30801 |
【开发单位】Ukrainian Academy of Pharmacy (Originator) 【药理作用】Non-Steroidal Antiinflammatory Drugs |
合成路线1
The cyclization of 2-hydroxybenzaldehyde (I) with 2-(cyanacetamido)benzoic acid methyl ester (II) catalyzed by piperidine in ethanol gives the 2-imino-1-benzopyran (III), which is then hydrolyzed to the target benzopyranone with HCl in refluxing ethanol/water.
【1】 Vasylyev, M.V.; Bilokin, Y.V.; Bylov, I.E.; Synthesis and antiinflammatory activity of N-substituted 2-oxo-2H-1-benzopyran-3-carboxamides and their 2-iminoanalagues. Eur J Med Chem 1999, 34, 11, 997. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 21351 | 2-Hydroxybenzaldehyde;Salicylic aldehyde;2-Formylphenol;salicylaldehyde | 90-02-8 | C7H6O2 | 详情 | 详情 |
(II) | 38049 | 1-[4-([[tert-butyl(dimethyl)silyl]oxy]methyl)phenyl]-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-ethanol | C20H34O4Si | 详情 | 详情 | |
(III) | 38410 | methyl 2-[[(2-imino-2H-chromen-3-yl)carbonyl]amino]benzoate | C18H14N2O4 | 详情 | 详情 |
Extended Information