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【结 构 式】 
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【药物名称】EUK-189 【化学名称】(SP-5-13)-(Acetato-kappaO)[[2,2'-[1,2-ethanediylbis[(nitrilo-kappaN)methylidyne]]bis[6-ethoxyphenolato-kappaO1]](2-)]manganese 【CA登记号】186350-27-6 【 分 子 式 】C22H25MnN2O6 【 分 子 量 】468.39235 |
【开发单位】Eukarion (Originator) 【药理作用】Alzheimer's Dementia, Treatment of , Antiparkinsonian Drugs, Cerebrovascular Diseases, Treatment of, Cognition Disorders, Treatment of, Extrapyramidal Disorders, Treatment of, NEUROLOGIC DRUGS, ONCOLYTIC DRUGS, Radioprotectants, Stroke, Treatment of, Free Radical Scavengers |
合成路线1
Condensation of the salicylaldehyde derivative (I) with ethylenediamine (II) affords the bis-imine (III). The title manganese complex is then obtained by treatment of (III) with manganese diacetate in ethanol.
| 【1】 Marcus, C.B.; Huffman, K.; Doctrow, S.R.; et al.; Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies. J Med Chem 2002, 45, 20, 4549. |
| 【2】 Malfroy-Camine, B.; Doctrow, S.R. (Eukarion, Inc.); Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease. JP 1999507646; US 5696109; WO 9640148; WO 9640149 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 56984 | 3-ethoxy-2-hydroxybenzaldehyde | C9H10O3 | 详情 | 详情 | |
| (II) | 14754 | ethylenediamine;1,2-Diaminoethane;ethane-1,2-diamine；1,2-Ethanediamine | 107-15-3 | C2H8N2 | 详情 | 详情 |
| (III) | 56985 | 2-ethoxy-6-{[(2-{[(E)-(3-ethoxy-2-hydroxyphenyl)methylidene]amino}ethyl)imino]methyl}phenol | C20H24N2O4 | 详情 | 详情 |
Extended Information