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【结 构 式】 
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【药物名称】PT-653 【化学名称】6-(5H-Dibenzo[b,f]azepin-5-ylmethyl)-2,4-pteridinediamine 【CA登记号】 【 分 子 式 】C21H17N7 【 分 子 量 】367.41654 |
【开发单位】Harvard Medical School (Originator), Indiana University (Originator) 【药理作用】AIDS Medicines, ANTIINFECTIVE THERAPY, Treatment of Opportunistic Infections |
合成路线1
Title compound is obtained by condensation of 6-(bromomethyl)pteridine-2,4-diamine (I) with dibenz[b,f]azepine (II) by means of NaH in THF..
| 【2】 Rosowsky, A. (Dana-Farber Cancer Institute); Pharmaceutically active cpds. and methods of use thereof. WO 0059884 . |
| 【1】 Cody, V.; Papoulis, A.T.; Rosowsky, A.; Galitsky, N.; Fu, H.; Queener, S.F.; Structure-based design of selective inhibitors of dihydrofolate reductase: Synthesis and antiparasitic activity of 2,4-diaminopteridine analogues with a bridged diarylamine side chain. J Med Chem 1999, 42, 23, 4853. |
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