|
【结 构 式】 
|
【药物名称】Proquazone, Arthrex 【化学名称】1-Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone 【CA登记号】22760-18-5 【 分 子 式 】C18H18N2O 【 分 子 量 】278.35696 |
【开发单位】Novartis (Originator) 【药理作用】Antiarthritic Drugs, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Antiinflammatory Drugs |
合成路线1
The condensation of 2-amino-4-methylbenzophenone (I) with isopropyl iodide (II) by means of sodium carbonate gives 4-methyl-2-isopropylaminobenzophenone (III), which is the cyclized with urethane (A) under the catalytic action of ZnCl2 at 190 C.
| 【1】 Castañer, J.; Thorpe, P.; Proquazone. Drugs Fut 1976, 1, 11, 540. |
| 【2】 Ott, H.; Denzer, M.; o-Isopropylaminobenzophenones. DE 180550,1; FR 2002598; GB 1248428 . |
Extended Information