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【结 构 式】 
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【药物名称】 【化学名称】1-[4-(4-Fluorophenyl)-4-oxobutyl]piperidine-4-carboxylic acid methyl ester 【CA登记号】 【 分 子 式 】C17H22FNO3 【 分 子 量 】307.36819 |
【开发单位】Central Drug Research Institute (Originator) 【药理作用】Antiarrhythmic Drugs, CARDIOVASCULAR DRUGS |
合成路线1
The reaction of piperidine-4-carboxylic acid (I) with SOCl2 gives the acyl chloride (II), which is treated with methanol to yield the methyl ester (III). Finally, this compound is condensed with 4-chloro-1-(4-fluorophenyl)-1-butanone (IV) by means of K2CO3 in refluxing acetone.
| 【1】 Kar, K.; Pandey, S.K.; Tripathi, R.C.; Saxena, A.K.; Synthesis and SAR studies of 1-substituted-n-(4-alkoxycarbonylpiperidin-1-yl)alkanes as potent antiarrhythmic agents. Bioorg Med Chem Lett 1999, 9, 18, 2693. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17402 | 4-nipecotic acid;piperidine-4-carboxylic acid;p-nipecotic acid; Isonipecotic acid; Hexahydroisonicotinic acid; 4-Piperidinecarboxylic acid | 498-94-2 | C6H11NO2 | 详情 | 详情 |
| (II) | 38417 | 4-piperidinecarbonyl chloride | C6H10ClNO | 详情 | 详情 | |
| (III) | 38418 | methyl 4-piperidinecarboxylate; Isonipecotic acid methyl ester; 4-piperidinecarboxylic acid methyl ester | 2971-79-1 | C7H13NO2 | 详情 | 详情 |
| (IV) | 35864 | 4-chloro-1-(4-fluorophenyl)-1-butanone | 3874-54-2 | C10H10ClFO | 详情 | 详情 |
Extended Information