-Drug Synthesis Database

【结构式】

【药物名称】

【化学名称】2-(2',4'-Dichlorobiphenyl-4-yl)-6-fluoroquinoline-4-carboxylic acid

【CA登记号】

【分子式】C₂₂H₁₂Cl₂FNO₂

【分子量】412.25084

【开发单位】Cubist (Originator)

【药理作用】Antibacterial Drugs, ANTIINFECTIVE THERAPY, Methionyl-tRNA Synthetase Inhibitors

合成路线1

The title quinolinecarboxylic acid was synthesized by Pfitzinger condensation of 5-fluoroisatin (I) with 1-(2',4'-dichlorobiphenyl-4-yl)ethanone (II) in the presence of KOH in aqueous EtOH.

参考文献中间体

【1】 Yu, X.Y.; et al.; Structure-activity relationship of biphenylquinoline analogs as inhbitors of S. aureus methionyl-TRNA synthetase. 218th ACS Natl Meet (Aug 22 1999, New Orleans) 1999, Abst MEDI 296.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	21552	5-fluoro-1H-indole-2,3-dione	443-69-6	C₈H₄FNO₂	详情	详情
(II)	35584	1-(2',4'-dichloro[1,1'-biphenyl]-4-yl)-1-ethanone		C₁₄H₁₀Cl₂O	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)