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【结 构 式】 
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【药物名称】 【化学名称】2-(4-Bromophenyl)-6-chloro-8-methylquinoline-4-carboxylic acid 【CA登记号】 【 分 子 式 】C17H11BrClNO2 【 分 子 量 】376.63972 |
【开发单位】Cubist (Originator) 【药理作用】Antifungal Agents, ANTIINFECTIVE THERAPY, PHARMACOLOGICAL TOOLS, Prolyl-tRNA Synthetase Inhibitors |
合成路线1
The title quinoline derivative was prepared by a Pfitzinger synthesis employing 5-chloro-7-methylisatin (I) and 4'-bromoacetophenone (II) in ethanolic KOH.
| 【1】 Hill, J.M.; Kluge, A.F.; Silverman, J.; Yang, Y.; Yu, G.; Finn, J.; Keith, D.; Yu, X.Y.; Gallant, P.; Structure-activity relationship of quinoline analogs as inhibitors of C. albicans prolyl t-RNA synthetase. 218th ACS Natl Meet (Aug 22 1999, New Orleans) 1999, Abst MEDI 289. |
Extended Information