【结 构 式】 |
【药物名称】[125I]-SB-258585 【化学名称】4-[125I]Iodo-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]benzenesulfonamide 【CA登记号】209480-63-7 (non-labeled) 【 分 子 式 】C18H22IN3O3S 【 分 子 量 】485.45834 |
【开发单位】GlaxoSmithKline (Originator) 【药理作用】Pharmacological Tools, 5-HT6 Antagonists |
合成路线1
The title sulfonamide was prepared by coupling 4-methoxy-3-(4-methylpiperazin-1-yl)aniline (II) with 4-iodobenzenesulfonyl chloride (I) in acetone.
【1】 Bromidge, S.M.; Brown, A.M.; Clarke, S.E.; Dodgson, K.; Gager, T.; Grassam, H.L.; Jeffrey, P.M.; Joiner, G.F.; King, F.D.; Middlemiss, D.N.; Moss, S.F.; Newman, H.; Riley, G.; Routledge, C.; Wyman, P.; 5-Chloro-N-(4-methoxy-3-piperazin-1-ylphenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046): A potent, selective, and orally bioavailable 5-HT6 receptor antagonist. J Med Chem 1999, 42, 2, 202. |
【2】 King, F.D.; Bromidge, S.M.; Wyman, P.A. (SmithKline Beecham plc); Sulphonamide derivs., process for their preparation, and their use as medicaments. WO 9827081 . |
Extended Information