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【结 构 式】 
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【药物名称】MRS-1595 【化学名称】N-(3,4-Dimethyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy]acetamide 【CA登记号】 【 分 子 式 】C25H28N6O6 【 分 子 量 】508.53851 |
【开发单位】National Institutes of Health (Originator), University of Virginia (Originator) 【药理作用】PHARMACOLOGICAL TOOLS, Adenosine A2B Antagonists |
合成路线1
Alkylation of 4-hydroxybenzaldehyde (I) with iodoacetic acid in the presence of K2CO3 afforded ether (II). Subsequent condensation of (II) with 5,6-diamino-1,3-dipropyluracil (III) gave imine (IV). Oxidative ring closure by means of FeCl3 in boiling EtOH, with concomitant esterification, furnished xanthine (V). The ethyl ester of (V) was then displaced by hydrazine to yield hydrazide (VI). Finally, condensation of (VI) with dimethylmaleic anhydride (VII) gave rise to the corresponding maleimide.
| 【1】 Jacobson, K.A.; et al.; Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors. J Med Chem 1985, 28, 9, 1334-40. |
| 【2】 Karton, Y.; Melman, N.; Ji, X.-D.; Jacobson, K.A.; Linden, J.; Kim, Y.-C.; Acyl-hydrazide derivatives of a xanthine carboxylic congener (XCC) as selective antagonists at human A2B adenosine receptors. Drug Dev Res 1999, 47, 4, 178. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 40086 | 2-iodoacetic acid | 64-69-7 | C2H3IO2 | 详情 | 详情 | |
| (I) | 13433 | 4-Hydroxybenzaldehyde; p-Hydroxybenzaldehyde | 123-08-0 | C7H6O2 | 详情 | 详情 |
| (II) | 25513 | 2-(4-Formylphenoxy)acetic acid; 4-Formyl phenoxy acetic acid | 22042-71-3 | C9H8O4 | 详情 | 详情 |
| (III) | 14628 | 5,6-diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione | C10H18N4O2 | 详情 | 详情 | |
| (IV) | 35608 | 2-(4-[[(6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-5-pyrimidinyl)imino]methyl]phenoxy)acetic acid | C19H24N4O5 | 详情 | 详情 | |
| (V) | 35609 | ethyl 2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy]acetate | C21H26N4O5 | 详情 | 详情 | |
| (VI) | 35610 | 2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy]acetohydrazide | C19H24N6O4 | 详情 | 详情 | |
| (VII) | 35611 | 3,4-dimethyl-2,5-furandione | 766-39-2 | C6H6O3 | 详情 | 详情 |