【结 构 式】 |
【药物名称】SCH-79797 【化学名称】N3-Cyclopropyl-7-(4-isopropylbenzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine 【CA登记号】245520-69-8 【 分 子 式 】C23H25N5 【 分 子 量 】371.4892 |
【开发单位】Schering-Plough (Originator) 【药理作用】Antiplatelet Therapy, CARDIOVASCULAR DRUGS, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS, Restenosis Treatment of, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, PAR1 Antagonists |
合成路线1
Alkylation of 5-nitroindole (I) with 4-isopropylbenzyl chloride (II) in the presence of Cs2CO3 provided the N-benzylindole derivative (III). Reduction of the nitro group of (III) by hydrogenation over Pd/C gave the corresponding amine, which was isolated as the hydrochloride salt (IV). The required pyrroloquinazoline system (V) was then prepared by reaction of (IV) with trichloromethyl isocyanate, followed by treatment with POCl3. Displacement of the 1-chlorine of (V) by ammonia afforded amine (VI). The remaining 3-chlorine of (VI) was then displaced by cyclopropylamine (VII) to furnish the title compound.
【1】 Boykow, G.; Ahn, H.-S.; Arik, L.; et al.; Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists. Bioorg Med Chem Lett 1999, 9, 14, 2073. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 26916 | 5-Nitroindole; 5-nitro-1H-indole | 6146-52-7 | C8H6N2O2 | 详情 | 详情 |
(II) | 33769 | 1-(chloromethyl)-4-isopropylbenzene | 2051-18-5 | C10H13Cl | 详情 | 详情 |
(III) | 33770 | 1-(4-isopropylbenzyl)-5-nitro-1H-indole | C18H18N2O2 | 详情 | 详情 | |
(IV) | 33771 | 1-(4-isopropylbenzyl)-1H-indol-5-amine; 1-(4-isopropylbenzyl)-1H-indol-5-ylamine | C18H20N2 | 详情 | 详情 | |
(V) | 33772 | 1,3-dichloro-7-(4-isopropylbenzyl)-7H-pyrrolo[3,2-f]quinazoline | C20H17Cl2N3 | 详情 | 详情 | |
(VI) | 33773 | 3-chloro-7-(4-isopropylbenzyl)-7H-pyrrolo[3,2-f]quinazolin-1-ylamine; 3-chloro-7-(4-isopropylbenzyl)-7H-pyrrolo[3,2-f]quinazolin-1-amine | C20H19ClN4 | 详情 | 详情 | |
(VII) | 12263 | Cyclopropylamine; Cyclopropanamine | 765-30-0 | C3H7N | 详情 | 详情 |