Elacytarabine;Elaidic acid Cytarabine;P-4055;CP-4055, -Drug Synthesis Database

【结构式】

【药物名称】Elacytarabine;Elaidic acid Cytarabine;P-4055;CP-4055

【化学名称】5'-O-[9(E)-Octadecenoyl]-1-beta-D-arabinofuranosylcytosine;4-Amino-1-[5-O-[9(E)-octadecenoyl]-beta-D-arabinofuranosyl]-2(1H)-pyrimidinone

【CA登记号】188181-42-2

【分子式】C₂₇H₄₅N₃O₆

【分子量】507.6762

【开发单位】Norsk Hydro (Originator)

【药理作用】ONCOLYTIC DRUGS；Antimetabolites

合成路线1

The title cytarabine 5'-ester was synthesized by condensation of cytarabine - HCl (I) with elaidoyl chloride (II) in DMA.

【1】 Borretzen, B.; Myhren, F.; Dalen, A.; Stokke, K.T. (Norsk Hydro AS); Improved therapeutic agents. WO 9705154 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	32709	Cytarabine; Cytosine Beta-D-Arabinofuranoside; 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2(1H)-pyrimidinone	147-94-4	C₉H₁₃N₃O₅	详情	详情
(II)	28280	Oleoyl chloride; (E)-9-Octadecenoyl chloride		C₁₈H₃₃ClO	详情	详情

Extended Information