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【结 构 式】 
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【药物名称】SW-68210 【化学名称】N-[1-[2-(Diethylamino)ethylamino]-10-oxo-10H-dibenzo[b,e]thiopyran-4-ylmethyl]carbamic acid methyl ester 【CA登记号】155990-11-7 【 分 子 式 】C22H27N3O3S 【 分 子 量 】413.54279 |
【开发单位】Sanofi-synthélabo (Originator) 【药理作用】ONCOLYTIC DRUGS |
合成路线1
The reaction of 1-[2-(diethylamino)ethylamino]-9-oxothioxanthene-4-carbaldehyde (I) with formic acid and formamide at 160 C gives N-[1-[2-(diethylamino)ethylamino]-9-oxothioxanthen-4-ylmethyl]formamide (II), which is hydrolyzed with hot aqueous HCl yielding the corresponding amine (III). Finally, this compound is acylated with methyl chloroformate and TEA in dichloromethane.
| 【1】 Brown, S.; Sandhu, G.S. (Sanofi-Synthelabo); Lyophilized thioxanthenone antitumor agents. WO 9710809 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 16993 | methyl chlorocarbonate;Carbonochloridic acid methyl ester；[(chlorocarbonyl)oxy]methane；methyl chloroformate | 79-22-1 | C2H3ClO2 | 详情 | 详情 | |
| (I) | 27504 | 1-[[2-(diethylamino)ethyl]amino]-9-oxo-9H-thioxanthene-4-carbaldehyde | C20H22N2O2S | 详情 | 详情 | |
| (II) | 27505 | (1-[[2-(diethylamino)ethyl]amino]-9-oxo-9H-thioxanthen-4-yl)methylformamide | C21H25N3O2S | 详情 | 详情 | |
| (III) | 27506 | 4-(aminomethyl)-1-[[2-(diethylamino)ethyl]amino]-9H-thioxanthen-9-one | C20H25N3OS | 详情 | 详情 |
Extended Information