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【结 构 式】 
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【药物名称】 【化学名称】1',2,3,3',4,4',5,5',6',7',7,8,8',9,9',10,10'-Heptadecahydro-6-mercapto-1,2'-bisdecaborate(4-) tetrasodium salt 【CA登记号】 【 分 子 式 】H18B20Na4S 【 分 子 量 】358.38666 |
【开发单位】Southwest Texas State University (Originator), University of California, Los Angeles (Originator) 【药理作用】Oncolytic Drugs |
合成路线1
The reaction of the normal isomer of eicosaborohydride anion (I) with potassium tert-butyl thiocarbonate (II) in refluxing THF produced the unexpected apical-apical isomer of the thiocarbonate borane (III). Acid cleavage of the thiocarbonate group afforded the target thiol derivative, which was isolated as the tetrasodium salt after treatment with an ion-exchange resin.
| 【1】 Feakes, D.A.; et al.; Synthesis and in vivo murine evaluation of Na4[1-(1'-B10H9)-6-SHB10H8] as a potential agent for boron neutron capture therapy. Proc Natl Acad Sci USA 1999, 96, 11, 6406. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 34599 | N-[(5S)-4-([(1R,3aR,7aR)-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexenyl]octahydro-4H-inden-4-ylidene]methyl)-5-[[tert-butyl(dimethyl)silyl]methyl]-3-[(4-methylphenyl)sulfonyl]-3,4,5,6,7,8-hexahydro-2lambda(4),3-benzoselenazin-2(1H)-ylidene]-4-met | C49H74N2O4S2SeSi | 详情 | 详情 |
Extended Information