J-109404, -Drug Synthesis Database

【结构式】

【药物名称】J-109404

【化学名称】1,11-Dihydroxy-12-(beta-D-glucopyranosyl)-6-[2-hydroxy-1-(hydroxymethyl)ethylamino]-12,13-dihydro-4cH-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,7aH)-dione

【CA登记号】

【分子式】C₂₉H₃₀N₄O₁₁

【分子量】610.58265

【开发单位】Banyu (Originator), Merck & Co. (Originator)

【药理作用】ONCOLYTIC DRUGS, DNA Topoisomerase I Inhibitors, DNA-Intercalating Drugs

合成路线1

The compound was prepared from the previously reported cyclic anhydride (I), upon condensation with 2-hydrazino-1,3-propanediol (II) in DMF at 80 C.

参考文献中间体

【1】 Ohkubo, M.; Kojiri, K.; Kondo, H.; et al.; Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506. Bioorg Med Chem Lett 1999, 9, 9, 1219.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	31433	1,11-dihydroxy-12-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]-4c,7a,12,13-tetrahydrofuro[3,4-c]indolo[2,3-a]carbazole-5,7-dione		C₂₆H₂₂N₂O₁₀	详情	详情
(II)	31434	2-hydrazino-1,3-propanediol		C₃H₁₀N₂O₂	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)