SCRC-2941-18, -Drug Synthesis Database

【结构式】

【药物名称】SCRC-2941-18

【化学名称】4-(4-Chlorophenyl)-5-methylthiazol-2-amine

【CA登记号】82632-77-7

【分子式】C₁₀H₉ClN₂S

【分子量】224.71363

【开发单位】Sagami (Originator)

【药理作用】Bone Diseases, Treatment of, IMMUNOMODULATING AGENTS, METABOLIC DRUGS, Treatment of Autoimmune Diseases, Treatment of Osteoporosis, Cytokine Production Inhibitors

合成路线1

Bromination of 4'-chloropropiophenone (I) afforded bromoketone (II). This was cyclized with thiourea (III) to produce the target 4-arylthiazole.

参考文献中间体

【1】 Hatanaka, Y.; Yamaguchi, K.; Kobori, T.; Tsuji, T.; Goda, K.; Yada, M.; 4-Phenylthiazole derivatives inhibit IL-6 secretion in osteoblastic cells and suppress bone weight loss in ovariectomized mice. Bioorg Med Chem Lett 1999, 9, 7, 957.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	29196	1-(4-Chlorophenyl)-1-propanone; 4-Chloropropiophenone	6285-05-8	C₉H₉ClO	详情	详情
(II)	29197	2-bromo-1-(4-chlorophenyl)-1-propanone		C₉H₈BrClO	详情	详情
(III)	10180	Thiourea	62-56-6	CH₄N₂S	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)