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【结 构 式】 
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【药物名称】 【化学名称】3-Hydroxy-2-methyl-1-[2-(1-piperidinyl)ethyl]pyridin-4(1H)-one dihydrobromide 【CA登记号】 【 分 子 式 】C13H22Br2N2O2 【 分 子 量 】398.14049 |
【开发单位】Hacettepe University (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Non-Opioid Analgesics, Antiinflammatory Drugs |
合成路线1
Maltol (I) was protected as the benzyl ether (II) by means of benzyl chloride, and subsequently treated with 1-(2-aminoethyl)piperidine (III) in refluxing ethanol to produce the substituted pyridone (IV). The benzyl protecting group of (IV) was finally removed with boron tribromide, yielding the title hydroxypyridone, which was isolated as the dihydrobromide salt.
| 【1】 Aytemir, M.D.; et al.; New 4(1H)-pyridinone derivatives as analgesic agents. Arzneim-Forsch Drug Res 1999, 49, 3, 250. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 19171 | 1-(Chloromethyl)benzene; Benzyl chloride | 100-44-7 | C7H7Cl | 详情 | 详情 | |
| (I) | 13671 | Hydroxymethylpyrone; 3-Hydroxy-2-methyl-4H-pyran-4-one；Maltol;3-Hydroxy-2-methyl-4-pyrone | 118-71-8 | C6H6O3 | 详情 | 详情 |
| (II) | 12074 | 3-(Benzyloxy)-2-methyl-4H-pyran-4-one；3-(benzyloxy)-2-methylpyran-4-one | 61049-69-2 | C13H12O3 | 详情 | 详情 |
| (III) | 24646 | 2-(1-piperidinyl)-1-ethanamine | 27578-60-5 | C7H16N2 | 详情 | 详情 |
| (IV) | 31300 | 3-(benzyloxy)-2-methyl-1-[2-(1-piperidinyl)ethyl]-4(1H)-pyridinone | C20H26N2O2 | 详情 | 详情 |
Extended Information