【结 构 式】 |
【药物名称】MPB-27 【化学名称】7-Chloro-6-hydroxybenzo[c]quinolizinium chloride 【CA登记号】191091-58-4 【 分 子 式 】C13H9Cl2NO 【 分 子 量 】266.12878 |
【开发单位】INSERM (Originator) 【药理作用】Cystic Fibrosis, Treatment of , RESPIRATORY DRUGS, CFTR Channel Activators, Protein Kinase C (PKC) Inhibitors |
合成路线1
The condensation of 2-methylpyridine (I) with 2,6-dichlorobenzonitrile (II) by means of BuLi and diisopropylamine in THF gives the vinyl derivative (III), which is cyclized by heating at 200 C.
【1】 Mettey, Y.; Vierfond, J.-M.; Benzo[c]quinoliziums: A new family of inhibitors for protein kinase CK II. Bioorg Med Chem Lett 1997, 7, 8, 961. |
【2】 Becq, F.; Mettey, Y.; Vierfond, J.-M.; Verrier, B.; Gola, M. (CNRS (Centre National de la Recherche Scientifique)); CFTR channel activator cpds. and pharmaceutical compsns. containing same. EP 0937044; WO 9805642 . |
Extended Information