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【结 构 式】 
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【药物名称】NSL-1406 【化学名称】N-[2-(4-Chlorophenyl)ethyl]-5-methylthieno[2,3-d]pyrimidin-4-amine 【CA登记号】 【 分 子 式 】C15H14ClN3S 【 分 子 量 】303.81593 |
【开发单位】Nippon Steel (Originator) 【药理作用】Bone Diseases, Treatment of, Bone Resorption Inhibitors, METABOLIC DRUGS, ONCOLYTIC DRUGS, Treatment of Osteoporosis, Integrin alphavbeta3 (Vitronectin) Antagonists |
合成路线1
By condensation of 4-chloro-5-methylthieno[2,3-d]pyrimidine (I) with 2-(4-chlorophenyl)ethylamine (II) by means of diisopropylethylamine (DIEA) in hot DMF.
| 【1】 Katada, J.; Iijima, K.; Muramatsu, M.; Hayashi, M.; Hayashi, Y.; Hattori, M.; Takami, M.; Yasuda, E.; Cytotoxic effects of NSL-1406, a new thienopyrimidine derivative, on leukocytes and osteoclasts. Bioorg Med Chem Lett 1999, 9, 6, 797. |
Extended Information