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【结 构 式】 
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【药物名称】 【化学名称】4-Chloro-N'-(4-methylphenyl)benzohydrazide 【CA登记号】54812-59-8 【 分 子 式 】C14H13ClN2O 【 分 子 量 】260.72551 |
【开发单位】R.W. Johnson (Originator) 【药理作用】Antiarthritic Drugs, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Cyclooxygenase-2 Inhibitors, Non-Steroidal Antiinflammatory Drugs |
合成路线1
The title hydrazide was prepared from 4-chlorobenzoic acid (I) via conversion to the corresponding acid chloride (II), followed by condensation with 4-methylphenylhydrazine (III).
| 【1】 Sui, Z.; et al.; 1,3-Diarylcycloalkano-[1,2-d]-pyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2. 217th ACS Natl Meet (March 21 1999, Anaheim) 1999, Abst MEDI 202. |
| 【2】 Ferro, M.P.; Sui, Z.; Guan, J.; et al.; 1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2. Bioorg Med Chem Lett 2000, 10, 6, 601. |
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